解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:STUDY OBJECTIVES:To develop and validate a self-assessment adherence tool for imatinib in patients with chronic myeloid leukemia (CML), and to correlate the use of this tool with response to treatment and adverse effects. DESIGN:Retrospective cohort study. SETTING:Regional cancer center in France. PATIENTS:Forty-six...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1174
更新日期:2013-02-01 00:00:00
abstract::Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1246
更新日期:2013-02-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether recommendations made by pharmacists and accepted by hospital physicians resulted in fewer postdischarge readmissions and urgent care visits compared with recommendations that were not implemented. DESIGN:Prospective substudy of pharmacist recommendations. SETTING:Tertiary care aca...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1164
更新日期:2013-01-01 00:00:00
abstract::Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1170
更新日期:2013-01-01 00:00:00
abstract::Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, complex, idiosyncratic drug reaction that can be fatal. Systemic symptoms include lymphadenopathy, hepatic failure, and possibly renal failure. The syndrome has been primarily associated with anticonvulsants, whereas antimicrobials are less ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1142
更新日期:2012-12-01 00:00:00
abstract:STUDY OBJECTIVE:To compare clinical and safety outcomes of warfarin therapy before and after implementation of a novel patient self-management (PSM) program in which patients received their venipuncture-derived international normalized ratio (INR) results through a secure online messaging system and adjusted their warf...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1139
更新日期:2012-12-01 00:00:00
abstract::During the past decade, patient safety issues during care transitions have gained greater attention at both the local and national level. Readmission rates to U.S. hospitals are high, often because of poor care transitions. Serious adverse drug events (ADEs) caused by an incomplete understanding of changes in complex ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1215
更新日期:2012-11-01 00:00:00
abstract::Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1127
更新日期:2012-11-01 00:00:00
abstract:STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01123
更新日期:2012-10-01 00:00:00
abstract::Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01178.x
更新日期:2012-09-01 00:00:00
abstract::Consensus guidelines recommend antimicrobial stewardship in all hospitals with the following goals in mind: appropriate and judicious use of antimicrobial agents leading to increased drug safety, reduced antimicrobial utilization, reduction in the development and selection of resistant organisms, cost containment, and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01162.x
更新日期:2012-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01095.x
更新日期:2012-07-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the annual cost of proton pump inhibitors (PPIs) in the United States and in the United Kingdom. DESIGN:Matched-cohort cost analysis. DATA SOURCES:U.K. General Practice Research Database (GPRD) and MarketScan Commercial Claims and Encounter Database, a large, U.S. self-insured medical claim...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/j.1875-9114.2012.01111.x
更新日期:2012-06-01 00:00:00
abstract::Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2011.01049.x
更新日期:2012-06-01 00:00:00
abstract::Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01035.x
更新日期:2012-05-01 00:00:00
abstract::In October 2009, a 2-day, multistakeholder, national conference was held in Rockville, Maryland, to discuss and propose methods to improve the drug-drug interaction (DDI) evidence base and its evaluation and integration into clinical decision support (CDS) systems. The conference featured participants representing con...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01024.x
更新日期:2012-04-01 00:00:00
abstract::Warfarin is considered a high-risk drug because of its narrow therapeutic window, variability in dose response, and multitude of drug and food interactions. Although travel advice is available for patients who are taking warfarin, it is geared toward patients who are traveling to developed countries and tends to be la...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01019.x
更新日期:2012-03-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether alvimopan for prevention of postoperative ileus in patients undergoing small- or large-bowel resection by laparotomy is associated with lower total costs compared with standard care. DESIGN:Pharmacoeconomic analysis using a formal decision model. DATA SOURCE:Four phase III clinica...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/PHAR.1047
更新日期:2012-02-01 00:00:00
abstract::This commentary from the 2010 Task Force on Acute Care Practice Model of the American College of Clinical Pharmacy was developed to compare and contrast the "unit-based" and "service-based" orientation of the clinical pharmacist within an acute care pharmacy practice model and to offer an informed opinion concerning w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/PHAR.1042
更新日期:2012-02-01 00:00:00
abstract::The prevalence of diabetes mellitus has grown to staggering numbers, and its incidence is expected to rise in the next 2 decades. The need for novel approaches to treat hyperglycemia cannot be ignored. Current agents have been shown to modestly improve glycemia and in some cases prevent complications of diabetes, but ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/PHAR.1010
更新日期:2012-01-01 00:00:00
abstract::The complexities of oral anticoagulation with warfarin have led to the search for more practical alternative agents. Novel direct factor IIa inhibitors and direct factor Xa inhibitors currently in development can be administered at a fixed dose and do not require routine coagulation monitoring and ongoing dosage adjus...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.12.1175
更新日期:2011-12-01 00:00:00
abstract:STUDY OBJECTIVES:To characterize the steady-state pharmacokinetics of intravenous levetiracetam in neurocritical care patients requiring seizure prophylaxis after a neurologic injury and to determine which dosing regimens achieve serum concentrations within the recommended therapeutic range of 6-20 μg/ml. DESIGN. Prosp...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.31.10.934
更新日期:2011-10-01 00:00:00
abstract::In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.9.887
更新日期:2011-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.8.742
更新日期:2011-08-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the incidence of Clostridium difficile infection (CDI) at one community hospital by identifying patients with stool samples positive for C. difficile toxin A or B, and to compare the incidence with a 2008 national estimate; and to determine which patient characteristics and concomitant ant...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.7.642
更新日期:2011-07-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the safety and efficacy of rabbit antithymocyte globulin (r-ATG) with basiliximab in renal transplant recipients for whom an early steroid withdrawal (ESW) regimen was planned. DESIGN:Single-center, retrospective, cohort study. SETTING:Tertiary care medical center, including inpatient hospi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.6.566
更新日期:2011-06-01 00:00:00
abstract::Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with significant morbidity and mortality. Clinical consequences of hyponatremia include neurologic dysfunction, decreased mental function, cerebral edema, gait disturbances and falls, osteoporosis, and fractures. Hy...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.5.5S
更新日期:2011-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect of standardized Ginkgo biloba leaf extracts (GBE) on outcome parameters of hemostasis associated with risk of bleeding. DESIGN:Meta-analysis of 18 randomized controlled trials. SUBJECTS:A total of 1985 adults were enrolled to receive either GBE or placebo; 87% were patients wit...
journal_title:Pharmacotherapy
pub_type: 杂志文章,meta分析,评审
doi:10.1592/phco.31.5.490
更新日期:2011-05-01 00:00:00
abstract::Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.4.424
更新日期:2011-04-01 00:00:00
abstract::Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.3.298
更新日期:2011-03-01 00:00:00
abstract::Clinical pharmacists must often interpret and use data derived from observational studies when making clinical decisions and recommendations, answering drug information questions, and educating patients about drug therapy. This is the third article in a three-part series intended to enhance clinical pharmacists' under...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.2.115
更新日期:2011-02-01 00:00:00
abstract::Cancer therapeutics is undergoing a revolution with the advent of new drugs that can selectively target molecules responsible for carcinogenesis and tumor growth. The type and mechanism of these targeting drugs vary. Some are small molecules that specifically target a binding site on a receptor or signal transduction ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.1.62
更新日期:2011-01-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.30.12.1229
更新日期:2010-12-01 00:00:00
abstract::Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare neurodegenerative disease caused by the decreased ability of cells to produce sufficient energy in the form of adenosine 5'-triphosphate. Although it is one of the most common maternally inherited mitochondrial...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.11.1179
更新日期:2010-11-01 00:00:00
abstract::Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.10.1021
更新日期:2010-10-01 00:00:00
abstract::Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...
journal_title:Pharmacotherapy
pub_type: 杂志文章,实务指引
doi:10.1592/phco.30.9.955
更新日期:2010-09-01 00:00:00
abstract::Recent literature has demonstrated significant improvements in neurologic outcomes in patients who have received induced hypothermia in the setting of out-of-hospital cardiac arrest. Through multiple metabolic mechanisms, the induction of hypothermia slows the progression and devastation of transient cerebral hypoxia....
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.8.830
更新日期:2010-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside therapy. DESIGN:Pharmacokinetic analysis. SETTING:Critical care un...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.30.7.654
更新日期:2010-07-01 00:00:00
abstract::Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.5.493
更新日期:2010-05-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.4.405
更新日期:2010-04-01 00:00:00